Mc-PEG4-Val-Ala-PAB-Exatecan

Mc-PEG4-Val-Ala-PAB-Exatecan is a Drug-linker conjugate for ADC. Mc-PEG4-Val-Ala-PAB-Exatecan contains the ADC linker (Mc-PEG4-Val-Ala-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631) [1].

Product Specifications

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.65

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O)=O)=O)=O)N[C@@H]3C(C4=C5CC3)=C(CN6C7=CC([C@@]8(O)CC)=C(COC8=O)C6=O)C7=NC4=CC(F)=C5C

Molecular Formula

C58H69FN8O16

Molecular Weight

1153.21

References & Citations

[1]Schmitt S, et al. Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody-Drug Conjugates. Mol Cancer Ther. 2024 Feb 1;23 (2) :199-211.