P38-α MAPK-IN-9
P38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor (Ki: 0.057 nM) . p38-α MAPK-IN-9 inhibits LPS (HY-D1056) induced TNFα production in hPBMCs (IC50: 18 nM) [1].
Product Specifications
CAS Number
[868272-50-8]
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Smiles
N#CC1=C(NC(C)C)N=C(N)N=C1NC2=CC(C(NC3=NOC=C3)=O)=CC=C2C
Molecular Formula
C19H20N8O2
Molecular Weight
392.41
References & Citations
[1]Liu C, et al. 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48 (20) :6261-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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