VU0631019

VU0631019 is a potent antagonist of 5-HT2B, with the IC50 of 29 nM. VU0631019 is predicted to have very limited potential for brain penetration in human subjects, as is predicted to be substrates for P-gp-mediated efflux in humans[1].

Product Specifications

CAS Number

[1235656-95-7]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=C(NCC1CCN(CC1)CC2=C(C)OC(C)=C2)NC3=C(Cl)C=CC=C3

Molecular Formula

C20H26ClN3O2

Molecular Weight

375.89

References & Citations

[1]Aaron M Bender, et al. Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen. Assay Drug Dev Technol. 2023 Apr;21 (3) :89-96.