BTK-IN-41

BTK-IN-41 (Compound 47) is the inhibitor for BTK with an IC50 of 5.4 nM. BTK-IN-41 inhibits the diffuse large B cell lymphoma cell TDM-8 with IC50 of 13.8 nM[1].

Product Specifications

CAS Number

[2251799-53-6]

UNSPSC

12352005

Target

Btk

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(NC3=NN(C)C4=C3C=NC(NC5=CC=C6C(C(C)NCC6)=C5)=N4)=C2

Molecular Formula

C31H29F3N8O

Molecular Weight

586.61

References & Citations

[1]KIM P, et al., Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient. WO2018208132