MC-25B
MC-25B is a specific FKBP12 PROTAC degrader. MC-25B degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a DCAF16-dependent mechanism. (Pink: FKBP12 ligand (HY-170988) ; Blue: E3 ligase ligand HY-170986) ; Black: linker (HY-128844) ; FKBP12 ligand+ linker (HY-170987) ) [1].
Product Specifications
UNSPSC
12352005
Target
FKBP
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(CN1CCN(C2=CC=CC(C(N3CCC(N(C4CC4)C(CCl)=O)CC3)=O)=C2)CC1)NCCCOCCOCCOCCCNC(COC5=CC=CC([C@H](OC([C@@H]6CCCCN6C(C(C(C)(C)CC)=O)=O)=O)CCC7=CC(OC)=C(OC)C=C7)=C5)=O
Molecular Formula
C65H92ClN7O14
Molecular Weight
1230.92
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
Curated Selection
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