LASSBio-1985

LASSBio-1985 is an NHLd inhibitor (nucleoside hydrolase from Leishmania donovani), with a Ki of 79 μM and an IC50 of 84.6 μM. LASSBio-1985 exhibits selective toxicity against Leishmania parasites, with no toxicity to mammalian cells, making it a promising candidate for research in the field of anti-infective therapies[1].

Product Specifications

UNSPSC

12352005

Target

Parasite

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(O)C1=CC=C(/C=N/NC([C@]2(O)C[C@@H](O)[C@H](OC(C)(C)O3)[C@H]3C2)=O)C=C1

Molecular Formula

C18H22N2O7

Molecular Weight

378.38

References & Citations

[1]Alves MA, et al. The discovery of a new uncompetitive inhibitor of nucleoside hydrolase from Leishmania donovani. Bioorg Chem. 2025 Mar;156:108209.