JPHM-2-167

JPHM-2-167 (Compound 11) is a selective PHD (prolyl hydroxylase domain enzyme) inhibitor. JPHM-2-167 inhibits PHD2, PHD3 with IC50s of 0.253 μM and 3.95 μM, respectively. JPHM-2-167 can be used for chronic kidney disease [1].

Product Specifications

CAS Number

[1258877-17-6]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

O=C(N(C1=CC=C(C2=CC=CC=C2)C=C1)C(N3C4=NC=CC=N4)=O)C3(CC5)CCN5CC6=NC=CC=C6C

Molecular Formula

C30H28N6O2

Molecular Weight

504.58

References & Citations

[1]Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 25;67 (2) :1393-1405.