Nur77 modulator 4
Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. Nur77 modulator 4 significantly induces Nur77 expression and apoptosis, showing excellent growth inhibition in HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, thereby inducing cell apoptosis. Nur77 modulator 4 can be used in cancer research applications [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; IRE1; Nuclear Hormone Receptor 4A/NR4A; PERK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(NNC(NC1=CC=CC=C1Cl)=O)NC2=CC3=C(NC(C45CC6CC(C5)CC(C6)C4)=C3)C=C2
Molecular Formula
C26H28ClN5O2
Molecular Weight
477.99
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
BCR (Breakpoint Cluster Region Protein, Renal Carcinoma Antigen NY-REN-26, BCR1, D22S11) APC
BCR (Breakpoint Cluster Region Protein, Renal Carcinoma Antigen NY-REN-26, BCR1, D22S11) APC
