TZEP7

TZEP7 is an EGFR kinase inhibitior in cancer cells. TZEP7 exhibits cytotoxic effects against cancer cell lines and induces apoptosis. TZEP7 demonstrates downregulation of antiapoptotic Bcl-2, upregulation of pro-apoptotic Bax, and increases caspase levels. TZEP7 is promising for research of anticancer agent[1].

Product Specifications

CAS Number

[2566714-41-6]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

ClC1=CC=C(C2=CC(C3=CC(C)=C(F)C=C3)=NC/C(S2)=C/C#CC4=CC=CC=C4)C=C1

Molecular Formula

C27H19ClFNS

Molecular Weight

443.96

References & Citations

[1]Atmaca H, et al. Novel Enyne-Modified 1,4-Thiazepines as Epidermal Growth Factor Receptor Inhibitors: Anticancer and Computational Studies. ACS Omega. 2024 Dec 26;10 (1) :821-832.