ND-L11B (TFA)
ND-L11B TFA is a potent degrader of nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with the DC50 of 1.48 and 0.8 μM, the Dmax is closed to 80 %[1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(COC1=CC(C2=NC=C(C(CN3C=NC4=C(N=CN=C34)N)=C2)N5C[C@](N)(CCC5)CC(F)F)=CC=C1F)NCCCCCCCCCCCN.O=C(O)C(F)(F)F
Molecular Formula
C39H52F6N10O4
Molecular Weight
838.89
References & Citations
[1]Linghao Hu, et al. Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms. Eur J Med Chem. 2025 Feb 5:283:117179.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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