PPARγ/δ modulator 2

PPARγ/δ modulator 2 (Compound 3h) is a PPARγ agonist and PPARδ antagonist. The Ki values for PPARγ and PPARδ are 2.8 μM and 43 nM, respectively. PPARγ/δ modulator 2 significantly enhances the production of Adiponectin and promotes adipogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) . PPARγ/δ modulator 2 can be used in the study of metabolic disorders associated with hypoadiponectinemia[1].

Product Specifications

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Smiles

O[C@H](C[Se]1)[C@@H](O)[C@@H]1CN2C(N=C(Cl)N=C3NCC4=CC=CC(I)=C4)=C3N=C2

Molecular Formula

C17H17ClIN5O2Se

Molecular Weight

564.67

References & Citations

[1]Choi H, et al. Design, synthesis and biological evaluation of truncated 1'-homologated 4'-selenonucleosides as PPARγ/δ dual modulators. Bioorg Chem. 2025 Jan;154:108042.