AS-254s
AS-254s is the inhibitor for absent, small, or homeotic-like 1 protein (ASH1L) with an IC50 of 94 nM (FP assay) . AS-254s exhibits antiproliferative activity against MLL1-rearranged leukemic cells with GI50 [1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Purity
98.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(C2=CC=C1CNC(C3CC4(C3)CCN(CC4)CCNC(C5=NC=CS5)=O)=O)N(C=C2C6=CC(C(N)=S)=CC=C6)C7CCOCC7
Molecular Formula
C36H41ClN6O3S2
Molecular Weight
705.33
References & Citations
[1]Huang G, et al., Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors. J Med Chem. 2025 Jan 9;68 (1) :174-195.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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