DefNEtTrp

DefNEtTrp is a Fe dual chelator ligand, consisting of the Def and Trp moieties. DefNEtTrp exhibits potent and broad-spectrum antiproliferative and cell death behavior in cancer cell lines. DefNEtTrp induces both apoptosis and ferroptosis and has cytotoxicity with an IC50 value of 0.77 μM[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Ferroptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC1=C(C2=NN(C3=CC=C(C(NCCNC(N/N=C/C4=C(N)C=CC=N4)=S)=O)C=C3)C(C5=CC=CC=C5O)=N2)C=CC=C1

Molecular Formula

C30H27N9O3S

Molecular Weight

593.66

References & Citations

[1]Rodríguez I, et al. DefNEtTrp: An Iron Dual Chelator Approach for Anticancer Application. JACS Au. 2024 Dec 4;4 (12) :4799-4808.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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