JNK-1-IN-5
JNK-1-IN-5 (Compound 14) is a potent JNK1 inhibitor with sub-nanomolar efficacy. JNK-1-IN-5 suppresses TGF-β-induced epithelial-mesenchymal transition. JNK-1-IN-5 is promising for research of anti-pulmonary fibrosis agent targeting JNK1[1].
Product Specifications
CAS Number
[3047794-08-8]
UNSPSC
12352005
Target
JNK
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Others
Smiles
O=C(C1=C(NC2=NC(NC3=CC=C(C(N4CC5OCC4C5)=O)C=C3)=NC=C2Br)C=CC=C1)N
Molecular Formula
C23H21BrN6O3
Molecular Weight
509.36
References & Citations
[1]Ren S, et al. Discovery of a selective and potent inhibitor of c-Jun N-terminal kinase 1 with anti-pulmonary fibrosis effect. Bioorg Med Chem Lett. 2025 Feb 1;116:130044.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1
Curated Selection
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