KF-52
KF-52 is a phosphofructokinase-1 (PFK1) inhibitor, with an IC50 of 2.1 μM. KF-52 significantly increases the OCR/ECAR (OCR: oxygen consumption rate; ECAR: extracellular acidification rate) ratio[1].
Product Specifications
CAS Number
[3104612-74-7]
UNSPSC
12352005
Target
Phosphatase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Purity
98.94
Smiles
[H][C@]1([C@H]([C@H]2C(O)=O)C(N(CCC3=C4NC5=C3C=CC=C5)[C@@H]4C(F)(F)F)=O)C[C@@]2(C=C1)[H]
Molecular Formula
C21H19F3N2O3
Molecular Weight
404.38
References & Citations
[1]Ryo Kakehi, et al. Asymmetric Synthesis, Structure Determination, and Biologic Evaluation of Isomers of TLAM as PFK1 Inhibitors. ACS Med Chem Lett. 2024 Dec 4;16 (1) :59-63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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