IBFAR2

IBFAR2, a BFAR inhibitor, restores the CD8+ TRM cell subset against solid tumors. iBFAR2 promotes JAK2-STAT1 association and STAT1 phosphorylation[1].

Product Specifications

CAS Number

[353484-02-3]

UNSPSC

12352005

Target

JAK; STAT

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

FC(F)(F)C1=CC=CC2=C1NC(C3=CC=C([N+]([O-])=O)C=C3)C4C2C=CC4

Molecular Formula

C19H15F3N2O2

Molecular Weight

360.33

References & Citations

[1]Siyu Pei, et al. Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity. Nat Aging. 2024 Dec;4 (12) :1828-1844.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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