E3 ligase Ligand 46
E3 ligase Ligand 46 is a ligand for E3 ligase, used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347) [1].
Product Specifications
CAS Number
[3033591-48-6]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O[C@H](C[C@H]1C(N[C@H](C2=CC=C(C=C2)C3=C(N=CS3)C)C)=O)CN1C([C@H](C(C)C)N=[N+]=[N-])=O
Molecular Formula
C22H28N6O3S
Molecular Weight
456.56
References & Citations
[1]Li Z, et al. Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders. J Med Chem. 2025 Jan 23;68 (2) :1134-1154.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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