Adhibin
Adhibin is an allosteric inhibitor for RhoGAP class IX myosin, that inhibits Myo9 ATPase in mammalian and invertebrate with IC50 of 2.5 µM and 2.6 µM. Adhibin binds to the ATPase of myosin, interfers with its motor function, blocks the RhoGTPase related signaling pathway, and affects the cell migration, adhesion and cell division. Adhibin can be used in research about cancer metastasis[1].
Product Specifications
UNSPSC
12352005
Target
Myosin
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
BrC1=CC2=C(NC3=C2C=C(Br)C=C3CO)C=C1
Molecular Formula
C13H9Br2NO
Molecular Weight
355.02
References & Citations
[1]Kyriazi D, et al., An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells. Nat Commun. 2024 Nov 16;15 (1) :9947.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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