BET-IN-28
BET-IN-28 (Compound 44) is a highly potent inhibitor of bromodomain and extra-terminal domain (BET), with an IC50 value of 4.47 nM against BRD4-BD1. BET-IN-28 blocks the interaction between BET proteins and N-acetylated lysine residues on histone tails, down-regulates certain genes. BET-IN-28 can be used for hematological malignancies and solid tumors study[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
OCCNC1=NN=C2C(N([C@@H](C3=NC=CC=C3)C4CCOCC4)C5=C2C=CC(C6=C(C)N=NN6C)=C5)=N1
Molecular Formula
C26H29N9O2
Molecular Weight
499.57
References & Citations
[1]Zaidi JM, et al. Discovery of Highly Potent BET Inhibitors based on a Tractable Tricyclic Scaffold. ACS Med Chem Lett. 2025 Mar 21;16 (4) :588-595.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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