PI3Kδ-IN-23
PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with the IC50 of 0.27 nM. PI3Kδ-IN-23 bounds to PI3Kδ by covalent-bonding interactions with Lys779. PI3Kδ-IN-23 plays an important role in cancer research[1].
Product Specifications
CAS Number
[3051828-81-7]
UNSPSC
12352005
Target
PI3K
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(OC1=CC=CC=C1)C2=CC(C3=NC(C(N[C@@H]4CN(CC4)C(C5CCOCC5)=O)=NC=N6)=C6C=C3)=CN=C2OC
Molecular Formula
C30H30N6O5
Molecular Weight
554.60
References & Citations
[1]Bo Yuan, et al. Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation. J Med Chem. 2024 Nov 28;67 (22) :20076-20099.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169983/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kδ
Curated Selection
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