CL5D
CL5D is an activator of protein deacetylase SIRT6. CL5D can significantly enhance the deacetylation activity of SIRT6 and improve its catalytic efficiency. CL5D regulates SIRT6 activity by promoting conformational changes, especially dependent on the role of Arg-65 residue. CL5D can be used to study the activation mechanism of SIRT6 and its function in metabolism, DNA repair and aging[1].
Product Specifications
CAS Number
[2488745-53-3]
UNSPSC
12352005
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Metabolic Disease
Smiles
O=C(C1=CC=C2C(N(C3=CC=C(N(C(C4=C(Cl)C=C(Cl)C=C4Cl)=O)C(C5=C(Cl)C=C(Cl)C=C5Cl)=O)C(Cl)=C3)C(C2=C1)=O)=O)O
Molecular Formula
C29H11Cl7N2O6
Molecular Weight
731.58
References & Citations
[1]Klein MA, et al. Mechanism of activation for the sirtuin 6 protein deacylase. J Biol Chem. 2020 Jan 31;295 (5) :1385-1399.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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