CJZ3

CJZ3 is an reversible inhibitor for P-glycoprotein (P-gp), that accumulates the drug (Rh123) in cells, and improve the permeability of the blood-brain barrier (BBB) [1].

Product Specifications

CAS Number

[766508-73-0]

UNSPSC

12352005

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Smiles

FC1=CC=C(C(N2CCN(CC2)CC3=CC=C(C(Cl)=C3)Cl)C4=CC=C(C=C4)F)C=C1

Molecular Formula

C24H22Cl2F2N2

Molecular Weight

447.35

References & Citations

[1]Ji BS, et al., CJZ3, a lomerizine derivative, modulates P-glycoprotein function in rat brain microvessel endothelial cells. Acta Pharmacol Sin. 2006 Apr;27 (4) :414-8.