(S) -AMG-628

(S) -AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374) . (S) -AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448) - and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S) -AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA- (HY-153808) induced inflammatory pain models[1].

Product Specifications

CAS Number

[862269-92-9]

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

CC(NC1=NC(C(S1)=CC=C2)=C2OC3=NC=NC(N4CCN(CC4)[C@H](C5=CC=C(C=C5)F)C)=C3)=O

Molecular Formula

C25H25FN6O2S

Molecular Weight

492.57

References & Citations

[1]Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50 (15) :3528-39.