PTX80

PTX80 is an antagonist of p62 with an IC50 value of 31.18 nM. PTX80 reduces tumor volume in an HCT116 colorectal cancer mouse xenograft model[1].

Product Specifications

CAS Number

[2376297-69-5]

UNSPSC

12352005

Target

P62

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.5700

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(/C(CN(C/1)S(CCCN(C)C)(=O)=O)=C/C2=CC=C(C=C2)C#N)C1=C\C3=CC=C(C=C3)C#N

Molecular Formula

C26H26N4O3S

Molecular Weight

474.57

References & Citations

[1]Ori Kalid, et al. PTX80, a novel compound targeting the autophagy receptor p62/SQSTM1 for treatment of cancer. Chem Biol Drug Des. 2022 Nov;100 (5) :623-638.|[2]Ori Kalid, et al. PTX80, a novel compound targeting the autophagy receptor p62/SQSTM1 for treatment of cancer. Chem Biol Drug Des. 2022 Nov;100 (5) :623-638.