21H7
21H7 is a selective inhibitor of the Wnt/b-catenin pathway. 21H7 markedly inhibits the growth of HFs. 21H7 potently decreases growth of breast and colon cancer cells[1][2].
Product Specifications
CAS Number
[217317-45-8]
UNSPSC
12352005
Target
Wnt
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=CC(C)=NC2=C1C=C(Br)C=C2)N/N=C/C3=C(O)C=CC=C3
Molecular Formula
C18H14BrN3O2
Molecular Weight
384.23
References & Citations
[1]Chang M, et al. PIM kinase inhibitors downregulate STAT3 (Tyr705) phosphorylation. Mol Cancer Ther. 2010 Sep;9 (9) :2478-87.|[2]Bao R, et al. Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PLoS One. 2012;7 (11) :e48670.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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