Mavatrep-d6

Mavatrep-d6 (JNJ-39439335-d6) is a deuterated labeled Mavatrep (HY-16935) . Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM) . Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain[1].

Product Specifications

Product Name Alternative

JNJ-39439335-d6

UNSPSC

12352005

Target

Isotope-Labeled Compounds; TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC(C([2H])([2H])[2H])(C1=CC=CC=C1C2=CC=C3N=C(NC3=C2)/C=C/C4=CC=C(C=C4)C(F)(F)F)C([2H])([2H])[2H]

Molecular Formula

C25H15D6F3N2O

Molecular Weight

428.48

References & Citations

[1]William H. Parsons, et al. Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2- (2-{2-[2- (4-Trifluoromethyl-phenyl) -vinyl]-1H-benzimidazol-5-yl}-phenyl) -propan-2-ol (Mavatrep) . J. Med. Chem. 2015, 58, 9, 3859-3874.