Apoptosis inducer 36

Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model[1].

Product Specifications

CAS Number

[2831492-41-0]

UNSPSC

12352211

Target

Apoptosis; Pyroptosis

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Cancer

Smiles

[H][C@@]12CC(C(O[C@@H]1CC[C@@]3([C@H](CC[C@]32[H])O[Si](C(C)C)(C(C)C)C(C)C)C)=O)=C

Molecular Formula

C23H40O3Si

Molecular Weight

392.65

References & Citations

[1]Wang J, et al., Discovery of novel sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells. Eur J Med Chem. 2025 Feb 12;288:117360.