K882
K882 (Compound 4e) is a Src inhibitor, with KD of 0.315 μM. K882 induces Apoptosis. K882 inhibits XIAP and Survivin. K882 inhibits the activation of PI3K/Akt/mTOR, Jak1/Stat3, Ras/MAPK signaling pathways. K882 shows anti-tumor activity against non-small cell lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; IAP; JAK; mTOR; p38 MAPK; Ras; Src; STAT; Survivin
Related Pathways
Apoptosis; Epigenetics; GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
COC1=CC(/C=C/C2=NC=NC3=CC=CC=C23)=C(OC)C=C1
Molecular Formula
C18H16N2O2
Molecular Weight
292.33
References & Citations
[1]Ma X, et al. Identification of a novel Src inhibitor K882 derived from quinazoline-based stilbenes with anti-NSCLC effect. Bioorg Chem. 2025 Mar;156:108185.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; PI3Kα; STAT3; XIAP
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