K882

K882 (Compound 4e) is a Src inhibitor, with KD of 0.315 μM. K882 induces Apoptosis. K882 inhibits XIAP and Survivin. K882 inhibits the activation of PI3K/Akt/mTOR, Jak1/Stat3, Ras/MAPK signaling pathways. K882 shows anti-tumor activity against non-small cell lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; IAP; JAK; mTOR; p38 MAPK; Ras; Src; STAT; Survivin

Related Pathways

Apoptosis; Epigenetics; GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

COC1=CC(/C=C/C2=NC=NC3=CC=CC=C23)=C(OC)C=C1

Molecular Formula

C18H16N2O2

Molecular Weight

292.33

References & Citations

[1]Ma X, et al. Identification of a novel Src inhibitor K882 derived from quinazoline-based stilbenes with anti-NSCLC effect. Bioorg Chem. 2025 Mar;156:108185.