LC3B recruiter 2

LC3B recruiter 2 (34R) is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), which directly binds to LC3B. LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 (HY-10008) through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex (with inhibitory effects on both) . Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity[1].

Product Specifications

CAS Number

[380636-64-6]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Atg8/LC3; Autophagy

Related Pathways

Autophagy

Field of Research

Cancer

Purity

98.11

Solubility

DMSO : 35 mg/mL (ultrasonic)

Smiles

CCN1C(NC2=CC(Cl)=CC=C2C1=O)=O

Molecular Formula

C10H9ClN2O2

Molecular Weight

224.64

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Zeng Y, et al. Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations. Eur J Med Chem. 2025 Apr 5;287:117293.