AZ14240475

AZ14240475 is a potent, selective, and brain-penetrant inhibitor of EGFR Ex20Ins mutants, with the pIC50 of 7.6. AZ14240475 plays an important role in cancer research[1].

Product Specifications

UNSPSC

12352101

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

C=CC(N1CC2=C(C1)N(C3=CC=NC=N3)C(C4=C(F)C=C(F)C(OC5=NC=CC(Cl)=C5)=C4)=N2)=O

Molecular Formula

C23H15ClF2N6O2

Molecular Weight

480.85

References & Citations

[1]William McCoull, et al. Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations. J Med Chem. 2025 Jan 27.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

Curated Selection

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