RET ligand-2
RET ligand-2 is a selective RET inhibitor. RET ligand-2 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC RET degraders with antitumor activity. RET ligand-2 can be used for the synthesis of RD-23 (HY-168867) [1].
Product Specifications
CAS Number
[3053537-08-6]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; RET
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COC1=NC=C(C=C1)CN2C3CC2CN(C3)C4=NC=C(C=C4)C5=CC(N6CC=C(CC6)N7CCNCC7)=CN8N=CC(C#N)=C58
Molecular Formula
C34H38N10O
Molecular Weight
602.73
References & Citations
[1]Hualong M, et al. Discovery of a Selective and Orally Bioavailable RET Degrader with Effectiveness in Various Mutations. J Med Chem. 2025 Jan 7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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