LTD4 antagonist 2

LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R) . LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1][2].

Product Specifications

CAS Number

[107813-86-5]

UNSPSC

12352005

Target

Leukotriene Receptor

Related Pathways

GPCR/G Protein

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

O=C(C1=CC(OCC2=NC3=C(C=C2)C=CC=C3)=CC=C1)O

Molecular Formula

C17H13NO3

Molecular Weight

279.29

References & Citations

[1]Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64 (22) :16512-16529.|[2]Musser JH, et al. N-[ (arylmethoxy) phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure. J Med Chem. 1990 Jan;33 (1) :240-5.