ε-Rhodomycinone

ε-Rhodomycinone is a bacterial metabolite found in S. griseoruber. It is a precursor to Rhodomycin D, which is an intermediate in the bioconversion of ε-rhodomycinone to Daunorubicin (HY-13062) and Doxorubicin (HY-15142R) [1][2][3].

Product Specifications

CAS Number

[21288-60-8]

UNSPSC

12352005

Target

Bacterial; Drug Intermediate

Related Pathways

Anti-infection; Others

Field of Research

Cancer; Infection; Neurological Disease

Smiles

COC([C@@H]1C2=C([C@H](C[C@]1(O)CC)O)C(O)=C3C(C(C4=CC=CC(O)=C4C3=O)=O)=C2O)=O

Molecular Formula

C22H20O9

Molecular Weight

428.39

References & Citations

[1]Podojil M, et al. Production of rhodomycins in Streptomyces griseoruber 4620. Folia Microbiol (Praha) . 1980;25 (6) :464-6.|[2]Olano C, et al. A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D. Chem Biol. 1999 Dec;6 (12) :845-55.|[3]Dickens ML, et al. In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA. J Bacteriol. 1997 Apr;179 (8) :2641-50.