(R) -AS-1

(R) -AS-1 is a selective positive allosteric modulator of the excitatory amino acid transporter 2 (EAAT2), with an EC50 of 11 nM. (R) -AS-1 (at doses of 60 and 90 mg/kg) increases spontaneous locomotor activity in mice. Additionally, it demonstrates anticonvulsant activity in mouse models of seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ), or electrical stimuli (32 or 44 mA), with ED50s of 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively. (R) -AS-1 can be used in neurological disease research[1].

Product Specifications

CAS Number

[2506367-95-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

EAAT

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Purity

99.90

Smiles

O=C(NCC1=CC=CC=C1)[C@H](N2C(CCC2=O)=O)C

Molecular Formula

C14H16N2O3

Molecular Weight

260.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Abram M, et al. Discovery of (R) -N-Benzyl-2- (2,5-dioxopyrrolidin-1-yl) propanamide [ (R) -AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo. J Med Chem. 2022 Sep 8;65 (17) :11703-11725.