PPARα/δ agonist 3

PPARα/δ agonist 3 (Compound 8) is the orally active agonist for PPAR, that activates PPARα, PPARδ and PPARγ with EC50s of 5.6, 3.4 and 1278 nM, respectively. PPARα/δ agonist 3 exhibits anticholestatic activity in mouse ANIT- or CDCA (HY-76847) -induced cholestatic liver disease models[1].

Product Specifications

CAS Number

[3050611-33-8]

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

CC(C)(OC1=C(C)C=C(CN2CCN(C3=CC=C(C(F)(F)F)C=C3)C2=O)C=C1C)C(O)=O

Molecular Formula

C23H25F3N2O4

Molecular Weight

450.45

References & Citations

[1]Fu Z, et al., Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases. Eur J Med Chem. 2025 Mar 15;286:117284.