FTO-IN-13
FTO-IN-13 (compound 8t) is a potent FTO inhibitor. FTO-IN-13 shows antiproliferative activity. FTO-IN-13 induces apoptosis. FTO-IN-13 decreases the protein expression of Bcl-2 and Caspase 3 active. FTO-IN-13 decreases MYC and CEBPA gene expression. FTO-IN-13 shows anticancer activity[1].
Product Specifications
CAS Number
[687600-25-5]
UNSPSC
12352005
Target
Apoptosis; Fat Mass and Obesity-associated Protein (FTO)
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=CC2=C(C=C1O)C=CC=C2)N/N=C/C3=CC(Br)=C(C(Br)=C3O)O
Molecular Formula
C18H12Br2N2O4
Molecular Weight
480.11
References & Citations
[1]Liang X, et al. Discovery of Novel RNA Demethylase FTO Inhibitors Featuring an Acylhydrazone Scaffold with Potent Antileukemia Activity. J Med Chem. 2025 Jan 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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