VB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5, 4996, 9.88 µM for PIM1, PIM2, PIM3, respectively. VB1080 shows cytotoxicity. VB1080 shows anthelmintic activity[1].
Product Specifications
UNSPSC
12352005
Target
Pim
Related Pathways
JAK/STAT Signaling
Field of Research
Cancer; Infection
Smiles
CN(CCC1)CCN1C(C2=CC(C3=CC=C(O3)/C=C4C(NC5=C/4C=CC=C5C)=O)=CC=C2)=O
Molecular Formula
C27H27N3O3
Molecular Weight
441.52
References & Citations
[1]Banas V, et al. Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections. ACS Infect Dis. 2025 Jan 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1; PIM2; PIM3
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