D-PheTrAP
D-PheTrAP is a bisubstrate analog inhibitor of 1-Deoxy-d-xylulose 5-phosphate synthase (DXPS) . D-PheTrAP inhibits Escherichia coli DXPS (EcDXPS) and Pseudomonas aeruginosa DXPS (PaDXPS) with IC50 values of 0.52 μM, 2.1 μM, 2.4 μM, and 1.7 μM for wild-type (WT) EcDXPS, EcA426E, WT PaDXPS, and PaE431A, respectively[1].
Product Specifications
CAS Number
[2241298-26-8]
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=P(OCCC1=CN([C@H](CC2=CC=CC=C2)C(O)=O)N=N1)(O)C(C)=O
Molecular Formula
C15H18N3O6P
Molecular Weight
367.29
References & Citations
[1]Henriquez S, et al. Bisubstrate Analog Inhibitors of DXP Synthase Show Species Specificity. Biochemistry. 2025 Jan 21;64 (2) :432-447.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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