(Z) -Rilpivirine
(Z) -Rilpivirine ((Z) -R278474) is the (Z) -isomer of Rilpivirine (HY-10574) . Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI) . It exhibits potent antiviral activity against both wild-type HIV (EC50 = 0.4 nM) and mutant strains (EC50 = 0.1-2.0 nM) [1].
Product Specifications
CAS Number
[500287-94-5]
Product Name Alternative
(Z) -R278474; (Z) -TMC278; (Z) -DB08864
UNSPSC
12352005
Target
Drug Isomer; HIV; Reverse Transcriptase
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
CC(C=C(C=C1C)/C=C\C#N)=C1NC2=NC(NC3=CC=C(C=C3)C#N)=NC=C2
Molecular Formula
C22H18N6
Molecular Weight
366.42
References & Citations
[1]Reilly SW, et al. Late-Stage Carbon Isotope Exchange of Aryl Nitriles through Ni-Catalyzed C-CN Bond Activation. J Am Chem Soc. 2021 Mar 31;143 (12) :4817-4823.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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