Decarbamoylmitomycin C

Decarbamoylmitomycin C, an analog of Mitomycin C (MC), is an DNA-alkylating agent. Decarbamoylmitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction[1].

Product Specifications

CAS Number

[26909-37-5]

UNSPSC

12352005

Target

ATM/ATR; Drug Derivative; MDM-2/p53

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

CO[C@]12N(C[C@@]3([H])[C@]2([H])N3)C4=C(C(C(N)=C(C4=O)C)=O)[C@H]1CO

Molecular Formula

C14H17N3O4

Molecular Weight

291.30

References & Citations

[1]Maggie Zheng, et al. Synthesis of Mitomycin C and decarbamoylmitomycin C N6 deoxyadenosine-adducts. Bioorg Chem. 2019 Nov:92:103280.|[2]Gu Xiao, et al. Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction. Cell Cycle. 2015;14 (5) :744-54.