Metamizole (hemimagnesium)

Metamizole (Dipyrone) hemimagnesium is an anti-inflammatory and antioxidant agent with the property of reducing body temperature. Metamizole hemimagnesium can decrease the levels of C-reactive protein (CRP) and interleukin 6 (IL-6) . It is also an orally active cyclooxygenase (COX) inhibitor. Metamizole hemimagnesium can inhibit cell proliferation and promote apoptosis. It can be used in the research of inflammation and fever[1].

Product Specifications

CAS Number

[6150-97-6]

Product Name Alternative

Dipyrone (hemimagnesium) ; Methamizole (hemimagnesium)

UNSPSC

12352005

Target

Apoptosis; COX; Interleukin Related

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C1C(N(CS(=O)([O-])=O)C)=C(C)N(C)N1C2=CC=CC=C2.[Mg+2].[0.5]

Molecular Formula

C13H17N3O4S.1/2Mg

Molecular Weight

322.50

References & Citations

[1]Gozzoli V, et al. Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response. Intensive Care Med. 2004 Mar;30 (3) :401-7.|[2]Ciftçi M, et al. Effects of metamizol and magnesium sulfate on enzyme activity of glucose 6-phosphate dehydrogenase from human erythrocyte in vitro and rat erythrocyte in vivo. Clin Biochem. 2001 Jun;34 (4) :297-302.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 4

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