(S) -LY-41

(S) -LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (S) -LY-41 is a potent and selective 5-HT1A receptor agonist. (S) -LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015) . (S) -LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (S) -LY-41 can induce the 5-HT behavioral syndrome. (S) -LY-41can be used for the research of neurological disease, such as depression and anxiety[1].

Product Specifications

CAS Number

[136296-40-7]

UNSPSC

12352005

Target

5-HT Receptor; Drug Derivative; Drug Isomer

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CC(C1=CC=CC2=C1C[C@@H](N(CCC)CCC)CC2)=O

Molecular Formula

C18H27NO

Molecular Weight

273.41

References & Citations

[1]Yu H, et al. (R) - and (S) -8-acetyl-2- (dipropylamino) tetralin (LY-41) : two novel 5-HT1A receptor agonists. Eur J Pharmacol. 1993 Jan 26;231 (1) :69-76.