Pam2Cys

Pam2Cys (Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis (palmitoyloxy) propyl]cysteine) is a selective agonist of dendritic cell TLR2, targeting the lipid portion of dendritic cells. Pam2Cys works by targeting and activating dendritic cells, thereby inducing strong immune responses, such as the production of specific antibodies. Pam2Cys enhances immunogenicity without the need for exogenous adjuvants. Pam2Cys can be applied to vaccine research, especially the development of lipopeptide vaccines against influenza A virus and other viruses to induce protective immune responses[1][2][3].

Product Specifications

CAS Number

[656831-18-4]

Product Name Alternative

Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis (palmitoyloxy) propyl]cysteine

UNSPSC

12352211

Target

Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C([C@@H](N)CSCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)O

Molecular Formula

C38H73NO6S

Molecular Weight

672.05

References & Citations

[1]Pejoski D, et al. A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody. Immunol Cell Biol. 2010 Jul;88 (5) :605-11.|[2]Franzoni G, et al. Targeting Toll-Like Receptor 2: Polarization of Porcine Macrophages by a Mycoplasma-Derived Pam2cys Lipopeptide. Vaccines (Basel) . 2021 Jun 23;9 (7) :692.|[3]Tan AC, et al. Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice. Mol Pharm. 2012 Sep 4;9 (9) :2710-8.