SM-8849

SM-8849 is a thiazole derivative with anti-arthritis activity. SM-8849 specifically targets and inactivates T cells involved in delayed-type hypersensitivity (DTH) reactions, thereby inhibiting the core immunopathological process of arthritis, but has little effect on the humoral immune process such as antibody production. In a mouse arthritis model induced by Type II Collagen (HY-NP003), SM-8849 significantly alleviated clinical symptoms, reduced bone destruction and joint damage. SM-8849 can be used for the study of autoimmune diseases such as rheumatoid arthritis[1][2].

Product Specifications

CAS Number

[113759-19-6]

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

FC1=C(C2=CC=CC=C2)C=CC(C(C)C3=CSC(NC)=N3)=C1

Molecular Formula

C18H17FN2S

Molecular Weight

312.40

References & Citations

[1]Nagai H, et al. The effect of SM-8849 on experimental arthritis in mice. Pharmacology. 1996 Jun;52 (6) :377-86.|[2]Nishikaku F, Koga Y. Suppression of murine collagen-induced arthritis by treatment with a novel thiazole derivative, SM-8849. Immunopharmacology. 1993 Jan-Feb;25 (1) :65-74.