SMER10
SMER10 is a small-molecule enhancer that can induce autophagy. SMER10 can increase the number of EGFP-LC3 positive autophagosoms in COS-7 and HeLa cells, promoting the conversion of LC3-I to autophagosome-associated LC3-II. SMER10 can efficiently promote the degradation of autophagy substrates, including the mutant huntingtin protein (EGFP-HDQ74) associated with Huntington's disease and the A53T α-synuclein protein associated with Parkinson's disease. SMER10 exerts neuroprotective effect[1].
Product Specifications
CAS Number
[221238-83-1]
UNSPSC
12352005
Target
Atg8/LC3; Autophagy; Huntingtin; α-synuclein
Related Pathways
Autophagy; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1C2=C(N=CN1N)C=3C=CC=CC3CC24CCCC4
Molecular Formula
C16H17N3O
Molecular Weight
267.33
References & Citations
[1]Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3 (6) :331-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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