VUF14480

VUF14480 is a partial agonist of histamine H4 (hH4) receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 binds covalently to hH4 receptor (pKi: 6.3 for hH4-WT receptor) . VUF14480 partially induces hH4 receptor-mediated G protein activation and β-arrestin2 recruitment. VUF14480 can be used in the research of inflammatory diseases[1].

Product Specifications

CAS Number

[1605304-31-1]

UNSPSC

12352005

Target

Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Inflammation/Immunology

Smiles

N=1C(=NC(=CC1C=2C=CC=CC2)N3CCN(C)CC3)C=C

Molecular Formula

C17H20N4

Molecular Weight

280.38

References & Citations

[1]Nijmeijer S, et al. Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 (3.36) of the human histamine H₄ receptor. Br J Pharmacol. 2013 Sep;170 (1) :89-100.