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Telapristone acetate

Telapristone acetate (CDB-4124) is a potent progesterone receptor (PR) modulator. Telapristone acetate inhibits the proliferation of ovarian cancer cells by inducing cell cycle arrest and apoptosis. Telapristone effectively inhibits the occurrence and development of spontaneous and chemically induced mammary tumors in rats. Telapristone acetate can be used for breast and ovarian cancer research[1][2].

Product Specifications

Product Name Alternative

CDB-4124

UNSPSC

12352005

Target

Apoptosis; CDK; PARP; Progesterone Receptor

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Endocrinology

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@]2(OC(C)=O)C(COC)=O)([H])[C@@]3([H])C([C@@H](C4=CC=C(N(C)C)C=C4)C1)=C(CC5)C(CC3)=CC5=O

Molecular Formula

C31H39NO5

Molecular Weight

505.65

References & Citations

[1]Carlos D Gamarra-Luques, et al. Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity. J Ovarian Res. 2014 Apr 27;7:45.|[2]Wiehle R, et al. CDB-4124, a progesterone receptor modulator, inhibits mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis. Cancer Prev Res (Phila) . 2011 Mar;4 (3) :414-24.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-16483/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[198414-31-2]

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