Squalamine (phosphate)

Squalamine phosphate (Compound ENT-01) is an orally active neuroprotective agent. Squalamine phosphate can displace α-Syn that is bound electrostatically to nerve cell membranes and prevent aggregation of α-Syn. Squalamine phosphate can be used for the research of neurological disease, such as Parkinson’s disease[1].

Product Specifications

CAS Number

[1309370-82-8]

Product Name Alternative

ENT 01; MSI-1256 (phosphate)

UNSPSC

12352211

Target

α-synuclein

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=P(O)(O)O.O[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CC[C@H](C(C)C)OS(=O)(O)=O)C)([H])[C@@]4([C@@](C[C@H](CC4)NCCCNCCCCN)([H])C1)C

Molecular Formula

C34H68N3O9PS

Molecular Weight

725.96

References & Citations

[1]Camilleri M, et al. Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial. Ann Intern Med. 2022 Dec;175 (12) :1666-1674.