AFB1-FapyGua

AFB1-FapyGua is a major Guanine (HY-Y1055) adduct in cells and AFB1-N7-Gua derivative. AFB1-FapyGua exhibits a high mutagenic effect[1][2].

Product Specifications

CAS Number

[65386-83-6]

UNSPSC

12352005

Target

Drug Derivative; Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Others

Smiles

O[C@@H]1[C@@]2([H])C3=C(O[C@@]2([H])O[C@H]1N(C4=C(NC(N)=NC4=O)N)C=O)C=C(OC)C(C5=C6C(CC5)=O)=C3OC6=O

Molecular Formula

C22H19N5O9

Molecular Weight

497.41

References & Citations

[1]Mohamed AA, et al. When less is more: The association between the expression of polymorphic CYPs and AFB1-induced HCC. Eur J Clin Invest. 2024 Dec;54 (12) :e14297. |[2]Yan S, et al. Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson. Environ Mol Mutagen. 2024 Apr;65 Suppl 1 (Suppl 1) :4-8.